A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant

J Med Chem. 1989 May;32(5):937-40. doi: 10.1021/jm00125a002.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyltransferases / antagonists & inhibitors*
  • Antineoplastic Agents / pharmacology
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Hydroxymethyl and Formyl Transferases*
  • Molecular Conformation
  • Phosphoribosylglycinamide Formyltransferase
  • Purines / biosynthesis*
  • Ribonucleotides / chemical synthesis*
  • Ribonucleotides / metabolism
  • Ribonucleotides / pharmacology

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Purines
  • Ribonucleotides
  • glycineamide ribonucleotide
  • ThioGar
  • Hydroxymethyl and Formyl Transferases
  • Phosphoribosylglycinamide Formyltransferase
  • Acyltransferases